Paraspeckles: Where Long Noncoding RNA Meets Phase Separation

Paraspeckles: nuclear bodies built on long noncoding RNA

Paraspeckles are ribonucleoprotein bodies found in the interchromatin space of mammalian cell nuclei. These structures play a role in regulating the expression of certain genes in differentiated cells by nuclear retention of RNA. The core paraspeckle proteins (PSF/SFPQ, P54NRB/NONO, and PSPC1 [paraspeckle protein 1]) are members of the DBHS (Drosophila melanogaster behavior, human splicing) fam...

Alternative 3'-end processing of long noncoding RNA initiates construction of nuclear paraspeckles.

Paraspeckles are unique subnuclear structures built around a specific long noncoding RNA, NEAT1, which is comprised of two isoforms produced by alternative 3'-end processing (NEAT1_1 and NEAT1_2). To address the precise molecular processes that lead to paraspeckle formation, we identified 35 paraspeckle proteins (PSPs), mainly by colocalization screening with a fluorescent protein-tagged full-l...

Alternative 30-end processing of long noncoding RNA initiates construction of nuclear paraspeckles

Takao Naganuma, Shinichi Nakagawa, Akie Tanigawa, Yasnory F Sasaki, Naoki Goshima and Tetsuro Hirose* Functional RNomics Team, Biomedicinal Information Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan, RNA Biology Laboratory, RIKEN Advanced Science Institute, Wako, Japan and Biological Systems Control Team, Biomedicinal Information Research ...

Jitter separation: Where science meets art

In an ideal world, rise and fall times would be infinitely fast and every edge of a digital stream would consistently fall the exact same time away from the last. The end result would be no jitter, no wiggling, and no eyes diagrams that suffer from being closed or close to closed. Unfortunately it is not a perfect world, and what once was conceived as an infinitely fast edge, becomes slower as ...

Long Noncoding RNA-GAS5